Enantioselective synthesis of 3-arylindole atropisomers via organocatalytic indolization of iminoquinones
نویسندگان
چکیده
The direct enantioselective construction of axially chiral 3-arylindole frameworks via nucleophilic addition 2-substituted indoles to iminoquinones has been achieved with high efficiencies under mild phosphoric acid (CPA) catalytic conditions. utility this method was demonstrated in successful scale-up syntheses without compromising the product yields and enantioselectivities. oxidation products heteroaryl-p-quinone monoimine, which could be subjected structural diversification nucleophiles.
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ژورنال
عنوان ژورنال: Chemical synthesis
سال: 2023
ISSN: ['2769-5247']
DOI: https://doi.org/10.20517/cs.2022.46